Vitamin D is a well-known fat-soluble vitamin which is essential in the homeostasis of calcium and phosphorus.Vitamin D deficiency causes skeletal disorders, including rickets, osteomalacia, and osteoporosis.However, recent studies revealing the immunomodulatory effects of vitamin D have opened up a new understanding and boxes possibility in this field.It has been proved that vitamin D is related to a variety of autoimmune diseases.
Type 1 diabetes mellitus (T1DM), being generally accepted as autoimmune mediated, is also proposed to be associated with the vitamin D status of the human body.Here, we reviewed briefly click here the epidemiological correlation between the vitamin D status and prevalence of T1DM, the possible mechanisms underlying this correlation, and clinical trials focusing on the therapeutic prospects of vitamin D in the treatment of T1DM.